Fig. 3: Cross- and within-population fine-mapping for EduYears in a genome-wide significant locus (rs12936234) in EAS with EduYears GWAS in EUR by using SuSiEx.
From: Shared genetic architectures of educational attainment in East Asian and European populations
a, Regional association plot in EAS. b, Regional association plot in EUR. c, Fine-mapping in EAS. d, Fine-mapping in EUR. e, Fine-mapping in cross-population. The x axis represents the chromosomal position for each panel. The y axis represents the −log10(P value) for the association of variants with EduYears in EAS and EUR for a and b, respectively. For the meta-analysis of EduYears in EAS, an IVW fixed-effect model was used. All P values were calculated by a two-sided test and not corrected for multiple testing. In a and b, LD estimates of surrounding SNPs with the index SNP are indicated by colour. The y axis represents the PIP of the SNPs included in the credible sets identified from fine-mapping in c to e. PIP is the probability of being the candidate causal variant for each SNP. We filtered out SNPs with P > 5 × 10−8. We marked the value of maximum PIP in each credible set, and we used different colours to distinguish each credible set. For example, there are one (pink points), two (green points and blue points) and three (green points, pink points and blue points) credible sets identified from EAS populations, EUR populations and cross-population, respectively.
