Extended Data Fig. 4: Mood and anxiety trait loadings onto common genetic factor, EUR ancestry. | Nature Human Behaviour

Extended Data Fig. 4: Mood and anxiety trait loadings onto common genetic factor, EUR ancestry.

From: Gene × environment effects and mediation involving adverse childhood events, mood and anxiety disorders, and substance dependence

Extended Data Fig. 4

The common genetic factor was produced using GenomicSEM-0.0.5c from GWAS of each input trait shown in the diagram. The GAD trait was constructed from three GWAS of anxiety-related traits that were jointly analyzed using MTAG (methods). Values attached to arrows from Fg to trait represent loading of trait onto the common factor. Bottom values represent residual variance in each trait that is unexplained by the common genetic factor. Standard error values are in parentheses. GAD = generalized anxiety disorder; MDD = major depressive disorder; PTSD = posttraumatic stress disorder; BIP = bipolar disorder.

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