Fig. 1: Differences in brain FCs and the performance of harmonization between asleep and awake states.
From: Charting brain functional development from birth to 6 years of age
a, FC matrices from a representative infant participant in both awake and asleep states, along with the predicted asleep state derived from the experimentally acquired scan during the awake state of the same participant. b, Averaged similarity index and mean absolute difference (MAD) between asleep and awake states, as well as harmonization performance using the ComBat algorithm, from nested 10-fold cross-validation using images from BCP-augmented data. Error bars represent standard errors. c, Statistical comparison of individual functional connections between asleep and awake states; significantly different connections depicted (linear mixed-effects model, \(P < 0.05\), FDR corrected, two-sided). d, The number of significantly altered FCs was calculated for each region. The most affected regions, which displayed the highest number of significantly altered FCs, include fusiform, calcarine, anterior and middle cingulate cortex, middle temporal gyrus, angular gyrus, temporal pole, putamen, thalamus and caudate.
