Children with DFNB9 deafness receiving gene therapy in either one ear or both ears exhibited enhanced activation in parts of the auditory speech cortex, which occurred as early as four weeks after surgery, as well as an improvement in measures of their mental development.
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References
Lv, J. et al. AAV1-hOTOF gene therapy for autosomal recessive deafness 9: a single-arm trial. Lancet 403, 2317–2325 (2024). This paper, from our team, reports clinical trial results on the safety and efficacy of gene therapy for individuals with DFNB9 deafness.
Wang, H. et al. Bilateral gene therapy in children with autosomal recessive deafness 9: single-arm trial results. Nat. Med. 30, 1898–1904 (2024). This paper, from our team, reports clinical trial results on the safety and efficacy of gene therapy for patients with DFNB9.
Qi, J. et al. AAV-mediated gene therapy restores hearing in patients with DFNB9 deafness. Adv. Sci. 11, e2306788 (2024). This paper reports clinical trial results on the safety and efficacy of gene therapy for individuals with DFNB9 deafness.
Armony, J. L. et al. The specificity of neural responses to music and their relation to voice processing: an fMRI-adaptation study. Neurosci. Lett. 593, 35–39 (2015). This article confirms the presence of a region in the anterior superior temporal gyrus that responds more strongly to music than voice.
Peretz, I. et al. Neural overlap in processing music and speech. Phil. Trans. R. Soc. Lond. B. Biol. Sci. 370, 1664 (2015). This review discusses neurological activity in processing music and speech.
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This is a summary of: Zhang, J. et al. Preliminary evidence for enhanced auditory cortex activation and mental development after gene therapy in children with autosomal recessive deafness 9. Nat. Hum. Behav. https://doi.org/10.1038/10.1038/s41562-025-02184-8 (2025).
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Changes in the auditory cortex of children receiving gene therapy for deafness. Nat Hum Behav 9, 1315–1316 (2025). https://doi.org/10.1038/s41562-025-02185-7
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DOI: https://doi.org/10.1038/s41562-025-02185-7
