Genome-wide association studies of monozygotic twins revealed genes associated with psychiatric and neurodevelopmental traits that are environmentally sensitive, which means their function might depend on environmental factors such as stress.
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References
Assary, E., Vincent, J. P., Keers, R. & Pluess, M. Gene-environment interaction and psychiatric disorders: review and future directions. Semin. Cell Dev. Biol. 77, 133–143 (2018). A review that presents an overview of gene–environment interaction studies of psychiatric disorders.
Paré, G., Cook, N. R., Ridker, P. M. & Chasman, D. I. On the use of variance per genotype as a tool to identify quantitative trait interaction effects: a report from the Women’s Genome Health Study. PLoS Genet. 6, e1000981 (2010). A research paper that applies a variance analysis approach to studying gene–environment interaction.
Jinks, J. L. & Fulker, D. W. Comparison of the biometrical genetical, MAVA, and classical approaches to the analysis of human behavior. Psychol. Bull. 73, 311–349 (1970). An article that discusses twin differences design in the analysis of trait variation.
Visscher, P. M. & Posthuma, D. Statistical power to detect genetic loci affecting environmental sensitivity. Behav. Genet. 40, 728–733 (2010). An article that discusses the power of monozygotic-based versus population-based variance analyses approaches to detect environmental sensitivity genetic loci.
Hagenbeek, F. A. et al. Maximizing the value of twin studies in health and behaviour. Nat. Hum. Behav. 7, 849–860 (2023). A review that presents the value of incorporating data from twins in molecular genetic research.
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This is a summary of: Assary, E. et al. Genetics of monozygotic twins reveals the impact of environmental sensitivity on psychiatric and neurodevelopmental phenotypes. Nat. Hum. Behav. https://doi.org/10.1038/s41562-025-02193-7 (2025).
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Mental health-related genes that are sensitive to the environment. Nat Hum Behav 9, 1535–1536 (2025). https://doi.org/10.1038/s41562-025-02201-w
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DOI: https://doi.org/10.1038/s41562-025-02201-w