We hypothesized that, if the olfactory system involves fine-grained sensorimotor feedback, similarly to what has been observed in other sensory systems, the brain might modulate sniffs in real time according to detailed perceptual features of odours. We analysed more than 13,000 sniffs in response to 160 distinct odours to show that sniff patterns reflect fine-grained perceptual information and are potentially modulated by the amygdala.
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References
Johnson, B. N. et al. Rapid olfactory processing implicates subcortical control of an olfactomotor system. J. Neurophysiol. 90, 1084–1094 (2003). One of the first studies that highlighted how sniffs might be modulated in response to odours.
Secundo, L. et al. Individual olfactory perception reveals meaningful nonolfactory genetic information. Proc. Natl Acad. Sci. USA 112, 8750–8755 (2015). This study highlights how olfactory perception can be highly individuated.
Sagar, V. et al. High-precision mapping reveals the structure of odor coding in the human brain. Nat. Neurosci. 26, 1595–1602 (2023). This study examines how odour perceptual space is subjectively encoded in various olfactory regions and provided the dataset for the current study.
Rhone, A. E. et al. A human amygdala site that inhibits respiration and elicits apnea in pediatric epilepsy. JCI Insight 5, e134852 (2020). This work shows the link between amygdala activity and respiratory control.
Nobis, W. P. et al. Amygdala-stimulation-induced apnea is attention and nasal-breathing dependent. Ann Neurol. 83, 460–471 (2018). This study links amygdala activity with nasal breathing modulation.
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This is a summary of: Sagar, V. et al. The human brain modulates sniffs according to fine-grained perceptual features of odours. Nat. Hum. Behav. https://doi.org/10.1038/s41562-025-02327-x (2025).
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Sniffing dynamics reflect fine differences in perception of odours. Nat Hum Behav 10, 14–15 (2026). https://doi.org/10.1038/s41562-025-02335-x
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DOI: https://doi.org/10.1038/s41562-025-02335-x