Extended Data Fig. 9: Correlation of NTN4 expression with malignant and BM markers.
From: Basement membrane stiffness determines metastases formation
a, Graph depicts the correlation between the Net4 (NTN4) gene expression level and the expression level of the malignant marker PAX8 in 31 ovarian cancer patients (Pearson’s p-value = 4.758 e−5, r = −0.6633402). b, Graph depicts the correlation between the Net4 (NTN4) gene expression level and the expression level of the malignant marker EPCAM in 31 ovarian cancer patients (Pearson’s p-value = 2.893 e−4, r = −0.6075367). c, Graph depicts the correlation between the Net4 (NTN4) gene expression level and the expression level of BM encoding genes (BM ssgsea score, calculated using R package GSVA) in 31 ovarian cancer patients (Pearson’s p-value = 2.734 e−4, r = 0.6094658). These graphs highlight a negative correlation of NTN4 expression with malignant cell markers and a positive correlation with BM encoding genes in ovarian cancer patients. d, Graph highlights the correlation of BM encoding genes with NTN4 expression levels within ovarian cancer patients (x-axis) to the Normal component of breast cancer patients (y-axis) (Pearson’s p-value = 0.031, r = 0.37). BM genes significantly correlating with NTN4 expression in both cancer types are indicated with black dots (Laminin α2 (LAMA2), fibulin-5 (FBLN5), and fibulin-3 (EFEMP1)).
