Extended Data Fig. 1: Distribution of Normal versus Disease components in breast cancer patients and association of Net4 with kidney cancer patient survival.
From: Basement membrane stiffness determines metastases formation
a, Plots of consensus vs. overall associations in the Disease components, the Normal components, and the nonDSGA data. Most significant association with survival is captured in the Normal component of data. b, Kaplan Meier survival (death) analysis using Cox proportional hazard models for association with survival of NTN4 expression levels in the Normal component of renal cell carcinoma. Survival analysis comparison of (tumor group 1) low levels of NTN4 (33 percentile) vs. (tumor group 2) high levels of NTN4 (67 percentile) in the Normal component of data. High levels of NTN4 show significant association with good survival with P value 0.0157. c, Kaplan Meier survival (recurrence) analysis for association with survival of NTN4 levels in the Normal component of renal cell carcinoma. Survival analysis comparison of (tumor group 1) low levels of NTN4 (33 percentile) vs. (tumor group 2) high levels of NTN4 (67 percentile) in Normal component of data. High levels of NTN4 showed significant association with good survival with P value 0.0252.
