Fig. 5: Increased intercellular adhesion endows cells with increased resistance to elimination.
From: Force transmission is a master regulator of mechanical cell competition
a, Spatial autocorrelation of the isotropic stress for each cell type. The zero crossing indicates the correlation length. n = 18 videos from N = 5 independent experiments. b, Average correlation length of the isotropic stress for each cell type. P values were obtained from an unpaired t-test. n = 18 videos from N = 5 independent experiments. c, Deformation of WT cells close to the interface. A confocal image showing the side views of actin (white), LifeAct-GFP in E-cad KO cells (green) and the nuclei. Top: example cell height in mixed culture. Bottom: infrequent increased height for WT cells. d, Colour-coded height projection of the actin signal in collision assay. e, Quantification of cell height in collision. E-cad KO cells exhibits a faster decrease in cell height with distance from the interface compared with WT. n = 15 positions from N = 2 independent experiments. f, Bright-field and fluorescence (E-cad KO, green) images of WT cells getting compacted without cell elimination. g, E-cad KO cells responding to island compaction through cell elimination. h, Sketch of the proposed mechanism. Data are presented as mean values ± s.d. Scale bars, 100 µm (d); 20 µm (g); 10 µm (c and f).
