Extended Data Fig. 4: Synaptic properties of ASMRs with tactile stimulation.
a, SS values of ASMRs with increasing tactile stimulation amplitudes. Different pressures ranging from 0.4 kPa to 33 kPa with a contact time of 5 s were applied to the ASMRs using an Al block. The SS values of both SA and FA ASMRs increased with the tactile stimulation amplitude and were saturated near 30 kPa pressure. In the observed SA-EPSC data, the \(\Delta\)IEPSC/IEPSC,i from touch to release was 2.1 at a pressure of 0.4 kPa and 2.8 at a pressure of 33 kPa. On the other hand, the \(\Delta\)IEPSC/IEPSC,i of FA-EPSC was 0.57 at a pressure of 0.4 kPa and 2.8 at a pressure of 33 kPa. b, SS values of ASMRs with increasing rates of tactile stimulation (0.2, 0.4, 0.6, and 0.8 Hz). 8 kPa of pressure was applied to the ASMRs using an Al block. The SS increased as the tactile stimulation rate increased. c, EPSC change ratio of ASMRs with increasing durations of tactile stimulation (0.1, 0.5, 1, 3, 5, 7 s). A pressure of 8 kPa was applied to the ASMRs using an Al block. The EPSC change ratio increased with longer duration times. d, Linearity of SS between SA- and FA-type mechanoreceptors with different numbers of touches. The linearity of FA-EPSC was higher than that of SA-EPSC, indicating a higher SS value in FA-EPSC (0.85) compared to SA-EPSC (0.58) after 100 stimulations.
