Extended Data Fig. 3: Virus titers in respiratory organs of infected mice.

Three mice per group were intranasally inoculated with 106 PFU of WT-KK001-I38 (H1N1pdm), MUT-KK001-I38T (H1N1pdm), WT-KK003-I38 (H1N1pdm), or MUT-KK003- I38T (H1N1pdm). Three mice per group were euthanized on Days 3 and 6 post-infection for virus titration. Virus titers in the nasal turbinates and lungs were determined by use of a plaque assay on hCK cells. Vertical bars show the mean. Points indicate data from individual mice.