Extended Data Fig. 4: Virulence in mice. | Nature Microbiology

Extended Data Fig. 4: Virulence in mice.

From: Influenza A variants with reduced susceptibility to baloxavir isolated from Japanese patients are fit and transmit through respiratory droplets

Extended Data Fig. 4

Five mice per group were intranasally inoculated with 106 PFU of WT-KK001-I38 (H1N1pdm), MUT-KK001-I38T (H1N1pdm), WT-KK003-I38 (H1N1pdm), or MUT-KK003- I38T (H1N1pdm), or MEM containing 0.3% BSA (mock). Body weights (a) and survival (b) were monitored daily for 11 days. The values for body weights are presented as the mean percentages of the starting weight ± SD. P-values were calculated by using pairwise comparisons after a linear mixed model analysis (*P < 0.05; **P < 0.01). Asterisks next to data points depict statistically significant differences between mutant and wild-type viruses. See Methods for more details regarding the statistical analysis.

Source data

Back to article page