Extended Data Fig. 8: Proteobacteria restore homeostatic upper airway IL-17A production and K. pneumoniae-induced TNF production in the upper airway during colonization. | Nature Microbiology

Extended Data Fig. 8: Proteobacteria restore homeostatic upper airway IL-17A production and K. pneumoniae-induced TNF production in the upper airway during colonization.

From: Commensal Bacteroidetes protect against Klebsiella pneumoniae colonization and transmission through IL-36 signalling

Extended Data Fig. 8

a, Experimental scheme for (b,c): “ABX” = MNVA in drinking water; “CC” = commensal consortia inoculation by oral gavage (see Materials and Methods); “Kp” = K. pneumoniae oral inoculation; and “Sample” = upper airway sampling day. Days relative to K. pneumoniae inoculation. b, Upper airway TNF levels in adult mice 1 day post-intranasal inoculation with K. pneumoniae (WT B5055) and unencapsulated K. pneumoniae (∆CPS B5055) (n=5 animals). c, Homeostatic upper airway IL-17A levels in adult mice on day 0 (without K. pneumoniae inoculation) (n=5). Statistical comparisons were made by Kruskal–Wallis test with Dunn’s correction for multiple comparisons, horizontal lines indicate median values, error bars are standard deviation.

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