Extended Data Fig. 3: Bacteroidetes protect against Klebsiella pneumoniae colonization in the intestine through immune signalling.
a, Experimental scheme for (b): “Antibiotics” = MNVA in drinking water; “MT” = microbiota transfer; “Kp” = K. pneumoniae oral inoculation; and “Sample” = fecal sampling day; “Dexa” = dexamethasone treatment. Days relative to K. pneumoniae inoculation. b, K. pneumoniae (OXA-48) burden in the feces of adult mice (n=6,7 animals). c,d,e): acronyms as in (a) with “CC” = commensal consortia inoculation by oral gavage (see Materials and Methods). (d,e) K. pneumoniae (OXA-48) burden (n=8 animals) (d) and K. pneumoniae (ST258) (n=6 animals) (e) in the feces of adult mice. (f) Experimental plan for (g): acronyms as in (a,c). (g) K. pneumoniae (OXA-48) burden (n=7,8 animals) in the feces of adult mice. All statistical comparisons were made by Mann-Whitney test (two-tailed), horizontal lines indicate median values, ND is none detected (limit of detection for K. pneumoniae in feces = 103 CFU/g).
