Extended Data Fig. 6: Analysis of neutralization titers for the sera with cross-neutralization activity.
a, Neutralization titers to SARS-CoV-2 pseudotyped virus for the sera with (n = 56) and without (n = 11) cross-neutralization activity to SARS-CoV and/or MERS-CoV. b, Comparison of neutralization titers to SARS-CoV-2 (n = 11) for the sera without cross-neutralization and with cross-neutralization to SARS-CoV (n = 44), MERS-CoV (n = 5), and both viruses (n = 7). c-e, Comparison of neutralization titer (specific and cross neutralization) for each serum that shows cross-neutralization activity. c, Neutralization titers to SARS-CoV and SARS-CoV-2 for those sera cross-neutralizing SARS-CoV (n = 44). d, Neutralization titers to MERS-CoV and SARS-CoV-2 for those sera cross-neutralizing MERS-CoV (n = 5). e, Neutralization titers to SARS-CoV, MERS-CoV, and SARS-CoV-2 for those sera cross-neutralizing both SARS-CoV and MERS-CoV (n = 7). Neutralization titers are log10-transformed. In a and b, data presented as median, interquartile range (25%-75%). Mann-Whitney U test is used to compare the difference between two groups (a). One-way ANOVA is used to compare the difference among multi-groups, and Tukey’s multiple comparisons test is used for intra-groups (b). In c-e, paired t test is used to analysis the difference between groups. p < 0.05 was considered to be significant difference between the groups.
