Extended Data Fig. 7: BF3086 and BF3134 are conserved and share a potential regulatory motif.
From: Spatially distinct physiology of Bacteroides fragilis within the proximal colon of gnotobiotic mice
a, Phylogeny of 92 Bacteroides and Parabacteroides strains74 showing the presence of BF3086 and BF3134 orthologues, with horizontal bar graphs indicating the percent protein sequence identity to the studied type strain (NCTC9343, highlighted with red font). The teal box indicates strains that can be confidently assigned to the B. fragilis species (average pairwise ANI78 between them is 98%, whereas it falls below 95% for the next-closest strains also labeled as B. fragilis). The black squares indicate the presence of the conserved upstream motif (0-2 mismatches), using the GLAM2Scan algorithm75. b, Sequence of the conserved motif upstream of both genes. The asterisk (*) at position 18 indicates a position that differs between the upstream regions of the glycosyl hydrolase (BF3086) and the sulfatase (BF3134). The glycosyl hydrolase upstream region has an “A” at this position, whereas the sulfatase upstream region has a deletion at this position.
