Extended Data Fig. 5: Orientation of the CBD domain and the blocker motif. | Nature Microbiology

Extended Data Fig. 5: Orientation of the CBD domain and the blocker motif.

From: Structure of severe fever with thrombocytopenia syndrome virus L protein elucidates the mechanisms of viral transcription initiation

Extended Data Fig. 5

This figure is related to Fig. 2. The structures of SFTSV-L a, FluA-vRNA PA-PB1-PB2 complex b, FluB1-vRNA PA-PB1-PB2 complex c, FluB-cRNA PA-PB1-PB2 complex d, and apo FluC PA-PB1-PB2 complex e, are aligned according to their CBD domains and are shown in the same orientation in the upper panels. Because the CBD domains from these structures are located different site from their own RdRp cores, other domains of these structures are in significantly distinct positions. In the lower panels, the CBD domain and its interacting fragments in these structures are shown in detail. The CBD domains are covered by molecular surface, and the other fragments are shown as cartoon diagrams. The residues constituting the cap-binding pockets are highlighted in red and the PB2 cap-627 linker3 is in blue. Note, the orientation of the detailed illustrations for FluB1 (c), FluB (d) and FluC (e) has a ~90° clockwise rotation for clear presentation. The residues occupy the cap-binding pockets of SFTSV-L and apo FluC PA-PB1-PB2 complex are displayed as spheres.

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