Extended Data Fig. 7: Comparison of the priming loop. | Nature Microbiology

Extended Data Fig. 7: Comparison of the priming loop.

From: Structure of severe fever with thrombocytopenia syndrome virus L protein elucidates the mechanisms of viral transcription initiation

Extended Data Fig. 7

a-d. The subdomains of the RdRp core and the PA-C-like domain of SFTSV-L (a), LACV-L (PDB code: 5AMR) (c) and FluA PA-PB1-PB2 (PDB code: 4WSB) (d) are covered by a molecular surface with the same color scheme as that in Fig. 4b. The priming loops in three structures are shown as white cartoons. The priming loop in SFTSV-L is enlarged and is covered with cryo-EM density in (b). The RdRp catalytic centers of the three polymerases are highlighted by the white circles. e, Density of motif F. The RdRp motifs A, B, D, F, H of SFTSV-L are shown as cartoon diagram with the same color scheme as that of Fig. 5a. Motif F is covered by the cryo-EM density.

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