Extended Data Fig. 4: The endoN domain.

a, The contacts between SFTSV-L endoN domain and other domains. The structure of SFTSV-L is displayed with the same color scheme in Fig. 1. The endoN domain is covered by a molecular surface, and other domains are shown as cartoon diagrams. The back view and the side view of the endoN domain are shown in the right panels. The interdomain interfaces on the endoN domain are indicated by the same color as each of the interacting domains, including the RdRp core, the PB2-N-like domain, the arm domain and the blocker motif, the CBD domain and the lariat domain. b, The orientation of the endoN domains in SFTSV-L and LACV-L. The structures of SFTSV-L and LACV-L 1750 are aligned according to their RdRp domains. The endoN domains of SFTSV-L and LACV-L are covered by molecular surface in forest green and smudge green, respectively. The active residues of each endoN domain are highlighted in orange. The polypeptide of other domains in SFTSV-L was represented as cartoon diagram. The cap-binding pocket in the CBD domain is highlighted by a red dotted circle. The distance from the cap-binding pocket to the position of the active center of LACV-L endoN domain is approximately 80 Å.