Extended Data Fig. 1: Variability in heritability. | Nature Microbiology

Extended Data Fig. 1: Variability in heritability.

From: Genome-wide associations of human gut microbiome variation and implications for causal inference analyses

Extended Data Fig. 1

Scatter plots of heritability estimates in the FGFP data set derived from rank normal, box-cox and log2 transformed abundance data (a, b); and estimates between the FGFP data and those previously published (c, d). (a) The plot compares rank normal transformed (x-axis) data to box-cox transformed data (y-axis). (b) The plot compares rank normal transformed (x-axis) data to log2 transformed data (y-axis). (c) The plot compares box-cox transformed data from FGFP (x-axis) and Goodrich et al. (y-axis). (d) The plot compares FGFP rank normal transformed data (x-axis) to the quantile-quantile normalized data of Davenport et al. (y-axis). The color of each point indicates a measure of average abundance in FGFP, and the size of each dot illustrates the prevalence for each taxon. The red line is a loess curve fit through the data. Confidence intervals of the fitted curve is shaded in grey. An estimate of the Spearman’s rho correlation coefficient between the data points is provided in the sub-title of each plot, along with its’ two-sided p-value. Sample size and heritability estimates can be found in Supplementary Table 3.

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