Extended Data Fig. 5: Evaluation of cytokine production upon C. albicans and C. auris mannan stimulation.
a, PBMC production of cytokines TNF-α, IL-6, IL-1β, and IL-1Ra after 24 h stimulation without (RPMI; negative control) or with purified mannans from C. albicans and C. auris strains in the presence of 10% heat-inactivated human serum, n = 7. b, PBMC production of cytokines IFN-γ (n = 6), IL-17 (n = 9), and IL-22 (n = 9) after 7 days hours stimulation without (RPMI; negative control) or with purified mannans from C. albicans and C. auris strains in the presence of 10% human serum. Graphs represent mean ± SEM, data pooled from at least two independent experiments. * p < 0.05, two-sided Wilcoxon matched pairs signed-rank test, comparing respective C. auris strains with C. albicans as control or reference species. Data used to make this figure can be found in Source Data Extended Data Fig. 5.
