Extended Data Fig. 6: Pharmacokinetics of fluoxazolevir.
Pharmacokinetic studies of fluoxazolevir were performed in (a) male CD-1 mouse, (b) male SD rat and (c) male beagle dog models (n = 3 animals). The concentration profiles of fluoxazolevir were measured after either a single PO dose of 10 mg/kg or a single IV dose of 3 mg/kg. Compound concentrations were measured by UPLC-MS/MS. d, Serum alanine aminotransferase (ALT) levels were measured in each animal model to assess the potential toxicity of fluoxazolevir in vivo. For CD-1 mice and SD rats, ALTs from the 10 mg/kg PO groups were shown, and for beagle dogs, the 3 mg/kg IV group was shown. Data are presented as mean values ± standard deviations.
