Extended Data Fig. 8: Maximal tolerable dose of fluoxazolevir in mice.
The study was performed by Pharmaron Inc. (Beijing, PR China). Single doses of fluoxazolevir (50 mg/kg, 100 mg/kg, 500 mg/kg and 1000 mg/kg) were administered via oral gavage to CD-1 mice (n = 3 mice per group) and observed for 3 days. Body weights of all animals were recorded daily. All study animals were monitored behavior such as respite, food and water consumption (by cage side checking), circling, eye/hair matting and any other abnormal effect. Any mortality and/or abnormal clinical signs were recorded. All animals were sacrificed for necropsy on day 3. Data are presented as mean values ± SEM.
