Extended Data Fig. 3: Ferret head-to-head transmission experiment addition shedding data and clinical data.
From: The furin cleavage site in the SARS-CoV-2 spike protein is required for transmission in ferrets
(a, b) Infectious virus titres of WT (orange) or ΔCS (blue) taken from donor ferret (a) and direct contact ferret (b) nasal washes as determined by TCID50. Dotted line indicates limit of detection of infectious virus. (c) Microneutralisation assay showing ferret post-infection serology. Threshold of detection was a neutralisation titre of 10 (dotted line). Serum taken 14 days post-infection. (d) Changes in donor and direct contact ferret body weights during the duration of the infection. (e) Changes in donor and direct contact ferret body temperatures during the duration of the infection.
