Fig. 5: Functional landscape of intestinal phages.
From: Metagenomic compendium of 189,680 DNA viruses from the human gut microbiome
a, Protein-coding viral genes were identified across all MGVs and compared with profile HMMs from five databases. b, Forty-five per cent of genes fail to match any HMM, 30% match an HMM of unknown function and 25% match an HMM of known function. c, The 11,837,198 genes were clustered at 30% AAI using MMseqs2 into 459,375 protein clusters. d, Size distribution of protein clusters. e, An accumulation curve of protein clusters has not reached an asymptote. f, Functional annotations for the largest 75 protein clusters. Reverse transcriptases are highlighted in red. g, Prediction of DGRs based on the combination of the reverse transcriptase gene (PF00078) and TR–VR pair identified using DGRscan. A large fraction of MGVs contain the DGR system. h, DGR prevalence across different categories of viruses. DGRs are most common in lysogenic, dsDNA viruses from the Myoviridae family.
