Extended Data Fig. 8: Global comparison between RBD-WT and RBD-62 shows overall similarity.
From: SARS-CoV-2 variant prediction and antiviral drug design are enabled by RBD in vitro evolution
(A) RBD-62 preserves its typical twisted five−stranded antiparallel β sheet (β1, β3-β5, and β10) with an extended insertion containing the short β5-β9 strands, α4, and η3 helices and loops. The biggest differences are pronounced between M470 and F490 (black circle). (B) The upper part comprising of three segments: R357–S371 (β2, α2), G381-V395 (α3), and F515-H534 (β11) is not resolved in the density map (blue ribbon, added from PDB ID: 6M0J).
