Extended Data Fig. 6: Functional microbial compositional analyses.

KOs were summarized to associated pathways and differential expression was calculated based on DESeq2 analysis. a, Gene Set Enrichment Analysis (GSEA) was used to compare the functional signatures identified in BAL metagenome and metatranscriptome as distinctly enriched for comparisons between clinical outcome groups. b, Bubble plot showing DESeq results of microbial functions found concordantly differentially enriched between clinical outcome groups (bubble size based on median relative abundance for those found statistically significant).