Fig. 2: SARS-CoV-2 viral load and virus metatranscriptome analyses. | Nature Microbiology

Fig. 2: SARS-CoV-2 viral load and virus metatranscriptome analyses.

From: Microbial signatures in the lower airways of mechanically ventilated COVID-19 patients associated with poor clinical outcome

Fig. 2

a,b, Copies of the SARS-CoV-2 N gene per ml, normalized to the human RNase P gene, comparing paired upper and lower airway samples (a) and levels in BAL comparing clinical outcome groups in 142 subjects (b). LLD, lowest level of detection at 0.3 normalized copies ml–1. Horizontal lines represent the median. *Two-sided Mann–Whitney U P = 0.038. **Two-sided Mann–Whitney U P = 0.001. c, Correlation analysis between levels of sgRNA and viral load as estimated by RT–PCR for the SARS-CoV-2 N gene levels. d,e, Bubble plot showing DESeq results of RNA viruses (d) and expressed DNA phages (e) enriched in each clinical outcome comparison (bubble size based on median relative abundance for those found to be statistically significant; the red dashed line separates positive (to the right) and negative (to the left) fold changes; text in blue indicates statistical significance).

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