Extended Data Fig. 8: Validation of associations between absolute abundance of Bifidobacterium species and faecal abundances of the aromatic lactic acids and human milk oligosaccharides in the CIG cohort.
Heatmaps illustrating linear mixed model coefficients (adjusted for subject and age) between the absolute abundance of Bifidobacterium species estimated by a, 16 S rRNA amplicon sequence variant analysis or b, species/subspecies-specific qPCR and faecal concentrations of aromatic lactic acids (ILA, PLA and 4-OH-PLA, n = 240) or relative faecal abundances of human milk oligosaccharides (2′FL/3FL, 3′SL/6′SL and LNT/LNnT, n = 228) in the CIG cohort. For both panels statistical significance was evaluated by false discovery rate-corrected p-values (two-sided tests) indicated by asterisks with *p < 0.05, **p < 0.01, ***p < 0.001 and ****p < 0.0001.
