Extended Data Fig. 1: Bifidobacterium species composition and aromatic lactic acids in partially breastfed and weaned infants aged 9 months from the SKOT cohort.
a, Pie chart of the average Bifidobacterium species composition given as percent of total Bifidobacterium abundance (n = 59 infants). Legend includes the average percent of each species compared to the total faecal microbiota community (See also Supplementary Data 1g). b, Left panel: Box and whiskers plot (line: median, box: IQR, whiskers: min-max) of faecal abundance of indolelactic acid (ILA), phenyllactic acid (PLA) and 4-hydroxyphenyllactic acid (4-OH-PLA) in partially breastfed (n = 24, red) and weaned (n = 35, blue) infants. Right panel: Box and whiskers plot (line: median, box: IQR, whiskers: min-max) of urine abundance of ILA, PLA and 4-OH-PLA in partially breastfed (n = 19, red) and weaned (n = 30, blue) infants. Statistical significance was evaluated by two-sided Mann–Whitney U-test. c, Heatmap of Spearman’s Rank correlation coefficients (two-sided tests) between the relative abundances of ILA, PLA and 4-OH-PLA measured in urine and the faecal relative abundance of Bifidobacterium species or faecal concentrations of ILA, PLA and 4-OH-PLA of the same infants (n = 49 infants). For all panels asterisks indicate statistical significance: *p < 0.05, **p < 0.01, ***p < 0.001 and ****p < 0.0001.
