Extended Data Fig. 2: In vivo production of aromatic lactic acids in previously germ-free mice colonized with either B. longum 105-A WT or type 4 ldh mutant.

a, CFU counts of B. longum 105-A WT or type 4 ldh mutant from caecal content of mice monocolonized with either the WT (n = 21) or type 4 ldh mutant strain (n = 29). Bars and error bars indicate median ± IQR. b–d, caecal concentrations of the aromatic lactic acids (indolelactic acid (ILA), phenyllactic acid (PLA) and 4-hydroxyphenyllactic acid (4-OH-PLA)) in mice monocolonized with either the WT (n = 21) or type 4 ldh mutant strain (n = 29). Line and error bars indicate median ± IQR. For all panels statistical significance was evaluated by two-sided Mann–Whitney U-tests.