Fig. 1: Crystal structure of the S glycoprotein RBD in complex with Fab AZD8895.
From: Genetic and structural basis for SARS-CoV-2 variant neutralization by a two-antibody cocktail
a, Cartoon representation of AZD8895 in complex with RBD. The AZD8895 heavy chain is shown in cyan, the light chain in magenta and the RBD in green. b, The structure of the AZD8895–RBD complex is superimposed onto the structure of the RBD–human ACE2 complex (PDB ID: 6M0J), using the RBD structure as the reference. The colour scheme of the RBD–AZD8895 complex is the same as that in a. The RBD in the RBD–ACE2 complex is coloured in blue and the human ACE2 peptidase domain in grey. c, Surface representation of the RBD epitope recognized by AZD8895. The epitope residues are coloured in green and labelled in black with the critical contact residue F486 labelled in white. d, Antibody–antigen interactions between AZD8895 and the RBD. The RBD is shown in the same surface representation and orientation as that in c. The AZD8895 paratope residues are shown in stick representation. The heavy chain is coloured in cyan and the light chain is coloured in magenta. The aromatic cage residues Y33, Y92, W98, F110 and W50 are all coloured with darker shades of blue or purple and labelled with an orange star.
