Fig. 3: Neutralizing antibody responses in individuals infected with B.1.1.7.
a, Serum neutralization against B.1.1.7 spike pseudotyped virus at different time windows (n = 79). The black lines represent the GMT. b, Neutralization of B.1.1.7 spike pseudotyped virus by sequential serum samples. Longitudinal samples from the same donor (n = 38 donors) are connected by a line. c, Comparison of homologous neutralization (that is, neutralization of WT pseudotyped virus by wave 1 sera (n = 27) and neutralization of B.1.1.7 pseudotyped virus by sera from B.1.1.7-infected individuals (n = 26)) at peak neutralization (21–35 days POS). Lines represent the GMT. P values were calculated using Mann–Whitney two-sided U-test. d, Cross-neutralizing activity of sera collected between days 10 and 60 POS from individuals infected with B.1.1.7 against four SARS-CoV-2 variants (n = 72). Each dot represents one individual, and matched data points for neutralization of different spike variants by the same serum sample are connected by lines. The red line represents the GMT against that virus (GMT values listed above graph columns). e, Cross-neutralizing activity of sera collected between days 10 and 60 POS from individuals infected in wave 1 against four SARS-CoV-2 variants (n = 35). Each set of dots connected by lines represents a serum sample. The red line represents the GMT against that virus (GMT values listed above graph columns). f, Comparison of the neutralization potency of B.1.1.7 sera against SARS-CoV-2 variants between individuals experiencing disease severity 0–3 (black, n = 35) or 4–5 (red, n = 44). The black lines represent the GMTs. P values were calculated using Mann–Whitney two-sided U-test. The horizontal dotted line represents the cut-off for the assay.
