Extended Data Fig. 3: In vivo association of BV status and vaginal Cys concentrations with microbiota composition.
a, Relationship between Nugent score-based BV status and cervicotype among the 53 women depicted in Fig. 3a. BV status and cervicotype were significantly associated (P = 1.902 ×10-11; two-sided Fisher’s Exact Test). b, Two-tailed Spearman correlation between relative Cys concentrations in cervicovaginal lavage (CVL) fluid and relative abundances of the species L. iners, and L. crispatus among the 142 women depicted in Fig. 3b-f, showing correlation coefficients (ρ) with unadjusted p-values. Linear regression lines (solid blue) with 95% confidence intervals calculated based on log-transformed abundances and concentrations are shown to assist visualization (L. crispatus: y = 0.77 + 0.25x; L. iners: y = 0.30 + 0.22x). The red dotted line represents the bacterial limit of detection (L.D.). c,d Per-sample relative abundances and cohort-level prevalence (fraction of samples from the cohort in which each taxon was detected) for each genus (c) or species (d) with ≥50% prevalence (panels correspond to main Figs. 3e and f, respectively). Purple and blue lines respectively represent median and interquartile range of relative abundances for each taxon.
