Fig. 3: Loci associated with itraconazole resistance linked to regions of high FST and selection. | Nature Microbiology

Fig. 3: Loci associated with itraconazole resistance linked to regions of high FST and selection.

From: Population genomics confirms acquisition of drug-resistant Aspergillus fumigatus infection by humans from the environment

Fig. 3

a, Scatterplot of Tajima’s D estimates for each chromosome for all isolates within clade A (left) and scatterplot of Tajima’s D estimates for each chromosome for all isolates within clade B (right). The position of cyp51A is highlighted in red. b, Scatterplot of sliding 10-kb non-overlapping window estimates of FST for each chromosome between isolates within clades A and B (top). Manhattan plot (bottom) for the treeWAS subsequent test (bottom) showing P values for all loci and a significant threshold of 0.01 (dashed red line), above which points indicate significant associations. The vertical red line in both plots denotes the position of cyp51A. c, Relative growth of null mutants (compared to A1160) of genes with significant loci identified in treeWAS on media containing itraconazole.

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