Fig. 4: Statistical analysis of the open pan-genome associates genes from itraconazole-resistant isolates within either clade A or B based on the prevalence of WT cyp51a.
a, Plot of Tettelin’s model on the pan-genome generated from all isolates. The red line indicates the median value from all permutations and the γ value indicates that the pan-genome (γ > 0) is classed as ‘open’. b, Venn diagram plotting genes occurring at least once within isolates from clades A and B and genes only found within isolates from clade A or B. c, Venn diagram plotting genes associated with clades A and B, itraconazole resistance/susceptibility and WT/mutant cyp51a. Associated genes obtained a Bonferroni P < 0.05 and were organized into groups based on log ORs, from the Scoary results. The numbers represent the gene numbers.
