Extended Data Fig. 7: Comparison of the in vitro antiviral efficacy between Y180 and PF-07321332. | Nature Microbiology

Extended Data Fig. 7: Comparison of the in vitro antiviral efficacy between Y180 and PF-07321332.

From: An orally available Mpro inhibitor is effective against wild-type SARS-CoV-2 and variants including Omicron

Extended Data Fig. 7

VeroE6-TMPRSS2 cells infected with wildtype SARS-CoV-2 at 0.01 MOI were treated with serially-diluted Y180 or PF-07321332. Lysates were harvested at 24 h.p.i. for the detection of polymerase (RdRp) gene copies with RT-qPCR (n = 6). All data are shown as mean ± SD. Data were obtained from three independent experiments. Statistical significance is assessed by Student’s t-test. n.s., not statistically significant, *** represented p < 0.001; **** represented p < 0.0001.

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