Extended Data Fig. 3: Epimerization in vivo of (R)-5b, d-(R)-6a and Y180 in rats. | Nature Microbiology

Extended Data Fig. 3: Epimerization in vivo of (R)-5b, d-(R)-6a and Y180 in rats.

From: An orally available Mpro inhibitor is effective against wild-type SARS-CoV-2 and variants including Omicron

Extended Data Fig. 3

(a-c) Plasma concentrations and ratios of (R)-5b, d-(R)-6a and Y180, and their corresponding epimers (S)-5b, (S)-5b and (S)-6c (with deuterium replaced by hydrogen; see Supplementary Fig. 9). All compounds were orally administrated in rats. Data are shown as mean ± SD, n = 3 biological replicates.

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