Fig. 2: Statistical analyses and data filtering for enhanced 3D-seq precision.
a,b, Average (n = 4) C•G-to-T•A transition frequency within the primary GcsR 3D-seq peak region (a) or a control region located 100,000 bp upstream (b), with positions coloured by the number of replicates in which a transition at that position was observed. c, Moving average (75 bp window) of C•G-to-T•A transition frequencies and the curve derived from our statistical model (black line) calculated from filtered 3D-seq data for the GcsR peak region (Methods). Y-coordinates for the model curve are scaled arbitrarily. d, Genome-wide moving average (75 bp window) of C•G-to-T•A transition frequencies calculated for GcsR 3D-seq data after filtering as in c.
