Fig. 4: Benchmarking 3D-seq with ChIP-seq.
a–c, Schematics depicting the P. aeruginosa genome locations of established binding motifs for GcsR (a), GacA (b) and a subset of FleQ sites (c). Positions of the corresponding 3D-seq and ChIP-seq peak centres defined in this study are mapped onto the regions, with extended distances to the binding site(s) centre highlighted (arrows). Colors of regulated genes and targeted sites indicate the associated regulator (orange, GcsR; green, GacA; blue, FleQ) d, Average distance between peaks detected by 3D-seq and ChIP-seq to the centre of the closest binding motif (left) or the midpoint of the region encompassed by multiple binding motifs (Centre, right) for the indicated regulators. n = 16 peaks detected by 3d-seq and 32 detected by ChIP-seq; boxes indicate median (centre) and 25th to 75th percentiles, whiskers indicate range.
