Extended Data Fig. 6: 76E1 is broadly resilient to natural mutations within its epitopes.
From: Neutralization mechanism of a human antibody with pan-coronavirus reactivity including SARS-CoV-2
a, Frequency of mutants within the 76E1 epitope based on 5,506,473 sequences of SARS-CoV-2 available on the National Genomics Data Center (NGDC) of China National Center for Bioinformation (CNCB) as of November 19, 2021. The mutation counts more than 15 for each substitution were shown with black and the others are shown in gray. 8 mutants were identified within the 76E1 epitope residues. b, The infectivity of SARS-CoV-2 pseudoviruses with each mutation as compared with the wide type pseudovirus. n = 6. The P values are analysed by two-sided unpaired t tests. ****P < 0.0001, ns, not significant. c, Neutralizing curves of 76E1 against SARS-CoV-2 pseudoviruses with mutations. n = 3. d, The mutation numbers and IC50 valves of 76E1 to each mutant. n.d., not detectable due to the lower virus infectivity. Data are shown as the mean ± s.d. (b,c). Representative data are shown from two independent experiments (b,c).
