Extended Data Fig. 3: Prophylatical treatment of 76E1 protects mice from SARS-CoV-2-induced disease.
From: Neutralization mechanism of a human antibody with pan-coronavirus reactivity including SARS-CoV-2
a, Study outline: A single dose of 150 mg/kg 76E1 (n = 5), 50 mg/kg 76E1 (n = 4) or PBS (n = 6) treatment was delivered intraperitoneally 24 hours before challenge the hACE2 transgenic mice with 3.4 x 104 PFU of SARS-CoV-2. b, The weight loss was monitored for 3 days. c, Lung virus titers were measured 3 days post-infection (d.p.i.) and are shown as log10 RNA copies per gram of lung tissue. The data were representative of two independent experiments. d, H&E staining of lung tissue sections at 3 d.p.i. Representative images are shown with low (top, scale bars, 500 µm) and high power (below, scale bars, 50 µm) from two independent experiments. Results are depicted as the mean ± s.d. The P values are analyzed by two-sided unpaired t tests. ****P < 0.0001, ns, not significant (b,c).
