Extended Data Fig. 4: Protein length differences of genes within QTL. | Nature Microbiology

Extended Data Fig. 4: Protein length differences of genes within QTL.

From: Uncontrolled transposition following RNAi loss causes hypermutation and antifungal drug resistance in clinical isolates of Cryptococcus neoformans

Extended Data Fig. 4

In the upper panels, points mark the strength of association (y-axis) between bi-allelic SNP sites and hypermutation for Chr3 and Chr11 (top left and right, respectively). Grey dashed lines depict the 95% confidence intervals (CI) of the two QTL. For the bi-allelic SNPs within the two QTL 95% CIs, P = 1.46868 × 10−5 (Kruskal–Wallis H-test). Lower panels show the predicted differences in lengths of proteins (y-axis) encoded by annotated genes in Bt65 compared to H99 within each 95% CI of the QTL (x-axis) on Chr3 and Chr11 (bottom left and right, respectively). The name of each gene with a predicted nonsense mutation is annotated. Blue and red colours denote the gene orientation.

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