Extended Data Fig. 7: Different conformations of catalytic flap and C-termini regions in crystal structures of IMPDH enzymes. | Nature Microbiology

Extended Data Fig. 7: Different conformations of catalytic flap and C-termini regions in crystal structures of IMPDH enzymes.

From: Diadenosine tetraphosphate regulates biosynthesis of GTP in Bacillus subtilis

Extended Data Fig. 7

a-f. Cartoon representations of the crystal structures of a. Ap4A-bound full-length B. subtilis (Bs) IMPDH, b. B. subtilis (Bs) IMPDH-ΔCBS, c. P. aeruginosa (Pa) IMPDH-ΔCBS (PDB-ID: 5AHL31), d. P. aeruginosa (Pa) IMPDH-ΔCBS with substrate IMP in the active site (PDB-ID: 5AHM31), e. A. gossypii (Ag) IMPDH-ΔCBS (PDB-ID: 4XWU32), and f. A. gossypii (Ag) IMPDH-ΔCBS with substrate IMP in the active site (PDB-ID: 4XTI32). The catalytic cysteine (green), catalytic flap (red) and C-termini (orange) where colored and denoted where possible.

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