Extended Data Fig. 5: Antibiotic depletion of lung or gut microbiota in mice. | Nature Microbiology

Extended Data Fig. 5: Antibiotic depletion of lung or gut microbiota in mice.

From: Multi-omics analyses of airway host–microbe interactions in chronic obstructive pulmonary disease identify potential therapeutic interventions

Extended Data Fig. 5

a) Barplot shows reduced bacterial load in mouse lung but not cecum when the antibiotics were intranasally administered (n = 5). b) Intranasal delivery of antibiotics resulted in significantly decreased load of Lactobacillus in the lung but not cecum in mice (n = 5). c) Intranasal delivery of antibiotics did not significantly alter the level of indole-3-acetic acid (IAA) in mouse serum (n = 5). d) Intragastrical and/or drinking water delivery of antibiotics resulted in significantly decreased total bacterial load in cecum but not lung in mice (n = 5). e) Intragastrical and/or drinking water delivery of antibiotics resulted in significantly decreased Lactobacillus load in cecum but not lung in mice (n = 5). f) Intragastrical and/or drinking water delivery of antibiotics did not significantly alter the level of IAA in mouse BALF (n = 5). Barplots are presented as mean ± SD. Significance was determined using two-sided Student’s t-test. Exact P-values are provided in Source Data. *** P < 0.001, ** P < 0.01, * P < 0.05, + P < 0.1.

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