Extended Data Fig. 6: Airway microbiome-derived indole-3-acetic acid (IAA) ameliorated lung function decline, neutrophilic inflammation and apoptosis. | Nature Microbiology

Extended Data Fig. 6: Airway microbiome-derived indole-3-acetic acid (IAA) ameliorated lung function decline, neutrophilic inflammation and apoptosis.

From: Multi-omics analyses of airway host–microbe interactions in chronic obstructive pulmonary disease identify potential therapeutic interventions

Extended Data Fig. 6

a) Barplot shows non-significantly increased forced vital capacity (FVC) by IAA in emphysema murine model (n = 5). b) Barplots shows decreased airway TNF-α, IL-1β, IL-6 and IL-17A levels by IAA in the emphysema murine model (n = 5). c) Barplot shows reduced IAA levels in the emphysema murine model (n = 5). d) Barplots show decreased emphysema, as measured by mean linear intercept and destruction index by IAA in the emphysema murine model (n = 5). e) Barplots for area of collagen deposition (μm2) per basement membrane perimeter (μm) and representative images of collagen deposition show decreased collagen deposition by IAA in the emphysema murine model (n = 5). f) Barplot shows increased CCND1 (Cyclin D1) mRNA level by IAA in the emphysema murine model (n = 5). g) Barplot shows increased macrophage over neutrophil percentage in BALF by IAA in the emphysema murine model (n = 5). h) Barplot shows decreased neutrophilic elastase by IAA in the emphysema murine model. Barplots are presented as mean ± SD. Significance was determined using two-sided Student’s t-test. Exact P-values are provided in Source Data. *** P < 0.001, ** P < 0.01, * P < 0.05, + P < 0.1.

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