Extended Data Fig. 9: The phenotypic effects of indole-3-acetic acid (IAA) were validated in a cigarette smoke (CS)-induced COPD murine model. | Nature Microbiology

Extended Data Fig. 9: The phenotypic effects of indole-3-acetic acid (IAA) were validated in a cigarette smoke (CS)-induced COPD murine model.

From: Multi-omics analyses of airway host–microbe interactions in chronic obstructive pulmonary disease identify potential therapeutic interventions

Extended Data Fig. 9

a) Barplot shows ameliorated lung function decline by IAA in CS-induced COPD murine model (n = 5). b) Barplot of lung histopathological score and representative H and E stained lung sections show reduced tissue injury by IAA in CS-induced COPD murine model (n = 5). c) Barplots show decreased emphysema, as measured by mean linear intercept and destruction index by IAA in CS-induced COPD murine model (n = 5). d) Barplots show decreased TNF-α, IL-1β, IL-6 and IL-17A levels by IAA in CS-induced COPD murine model (n = 5). e) TUNEL assay and representative fluorescence images show decreased apoptotic rates by IAA in CS-induced COPD murine model (n = 5). TUNEL-positive cells are indicated in white arrows. Barplots are presented as mean ± SD. Significance was determined using two-sided Student’s t-test. Exact P-values are provided in Source Data. *** P < 0.001, ** P < 0.01, * P < 0.05, + P < 0.1.

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