Fig. 4: AN15368 uniformly cures chronically infected rhesus macaques.
a, Structure of drug trial with indicated treatment period and sampling dates. b, Summary of post-treatment detection of infection using PCR of parasite DNA in blood or tissue (either from individual tissue samples or pools of 5 individual samples/determination; see Methods and Supplementary Tables 8–10 for details) and haemoculture in drug-treated (T1–T19) and untreated control (C1–3) macaques. Samples were taken at the 7 time points indicated in a and yearly thereafter for animals T1–T19 that were not euthanized and thus not tissue sampled for PCR. Fractions in the table (for example ‘0/7’) indicate the number of positive results per total number of samples analysed. c, Representative pre- and post-treatment IgG responses to recombinant T. cruzi proteins in control animal C3 and treated animal T19 (see Methods for identification and Extended Data Fig. 3 for remaining animals). MFI, mean fluorescence intensity. ND, not done.
