Extended Data Fig. 1: Structure activity relationships of benzoxaboroles and their activity on different genetic types of T. cruzi. | Nature Microbiology

Extended Data Fig. 1: Structure activity relationships of benzoxaboroles and their activity on different genetic types of T. cruzi.

From: Discovery of an orally active benzoxaborole prodrug effective in the treatment of Chagas disease in non-human primates

Extended Data Fig. 1

a. Substitutions in the benzoxaborole ring C(7) position of AN10443 strongly affects in vitro activity against T. cruzi, with larger substitutions decreasing activity. b. T. cruzi of diverse genetic types (DTUs) are susceptible to AN14353-mediated killing (n = 3 biological replicates for each profile determination).

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