Extended Data Fig. 4: Replication and monitoring of CpG reversion during passage of CpG enriched HIV-1.
From: Rational attenuation of RNA viruses with zinc finger antiviral protein
(a) Replication of the CG-43 HIV-1 mutant in ZAP-deficient MT4 cells in three replicate cultures (Rep1-3). Percentage of infected cells was monitored by flow cytometry. (b, c) Sequence analysis of CG-15 HIV-1 mutant during replication. Unique point mutations in each replicate (b) and the total number of CpGs in each replicate at each passage (c) are indicated.
